HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Telmisartan sodium
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Telmisartan | HCID 65999 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Telmisartan sodium | HCID 23677803 | — |
Reaction Steps
10 g of telmisartan are suspended in 40 ml of THF in a round-bottom flask equipped with magnetic stirrer, condenser and under nitrogen atmosphere. The solution is added with 1.5 ml of 50% aq NaOH and the mixture is heated under reflux, then evaporated to a residue. 10.4 g of telmisartan sodium salt are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07692027B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-87c6da609eb34a848e1111abdbefae64 |
| Source note | uspto-grants-2010_04 |