HRID640749

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

结构：CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1

HCID65999

Telmisartan

C33H30N4O2

PRODUCTS

生成物

结构：CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)[O-])cc1.[Na+]

HCID23677803

Telmisartan sodium

C33H29N4NaO2

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

10 g of telmisartan are suspended in 40 ml of THF in a round-bottom flask equipped with magnetic stirrer, condenser and under nitrogen atmosphere. The solution is added with 1.5 ml of 50% aq NaOH and the mixture is heated under reflux, then evaporated to a residue. 10.4 g of telmisartan sodium salt are obtained.

WORKUP

后处理

customequipped with magnetic stirrer, condenser and under nitrogen atmosphere
temperaturethe mixture is heated
temperatureunder reflux
customevaporated to a residue

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-87c6da609eb34a848e1111abdbefae64
来源数据集: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07692027B2
来源说明: uspto-grants-2010_04

反应 SMILES

[CH3:1][C:2]1[C:10]2[N:9]=[C:8]([CH2:11][CH2:12][CH3:13])[N:7]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([C:21]4[C:22]([C:27]([OH:29])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=4)=[CH:17][CH:16]=3)[C:6]=2[CH:5]=[C:4]([C:30]2[N:34]([CH3:35])[C:33]3[CH:36]=[CH:37][CH:38]=[CH:39][C:32]=3[N:31]=2)[CH:3]=1.[OH-].[Na+:41]>C1COCC1>[Na+:41].[CH3:1][C:2]1[C:10]2[N:9]=[C:8]([CH2:11][CH2:12][CH3:13])[N:7]([CH2:14][C:15]3[CH:16]=[CH:17][C:18]([C:21]4[C:22]([C:27]([O-:29])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=4)=[CH:19][CH:20]=3)[C:6]=2[CH:5]=[C:4]([C:30]2[N:34]([CH3:35])[C:33]3[CH:36]=[CH:37][CH:38]=[CH:39][C:32]=3[N:31]=2)[CH:3]=1