反应详情

10 g of telmisartan are suspended in 70 ml of methanol in a round-bottom flask equipped with magnetic stirrer, condenser and under nitrogen atmosphere. The solution is added with 2.0 ml of a 37% HCl aqueous solution and the mixture is heated under reflux, then cooled to room temperature. The resulting precipitate is filtered and dried under vacuum at 55° C. to obtain 7.5 g of telmisartan hydrochloride.

1. customequipped with magnetic stirrer, condenser and under nitrogen atmosphere
2. temperaturethe mixture is heated
3. temperatureunder reflux
4. filtrationThe resulting precipitate is filtered
5. customdried under vacuum at 55° C.