Hydrochloric Acid → Telmisartan Hydrochloride

HRID 640750Notes

Reaction equation

HRID 640750 reaction equation
[CH3:1][C:2]1[C:10]2[N:9]=[C:8]([CH2:11][CH2:12][CH3:13])[N:7]([CH2:14][C:15]3[CH:20]=[CH:19][C:18]([C:21]4[C:22]([C:27]([OH:29])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=4)=[CH:17][CH:16]=3)[C:6]=2[CH:5]=[C:4]([C:30]2[N:34]([CH3:35])[C:33]3[CH:36]=[CH:37][CH:38]=[CH:39][C:32]=3[N:31]=2)[CH:3]=1.[ClH:40]>CO>[ClH:40].[CH3:1][C:2]1[C:10]2[N:9]=[C:8]([CH2:11][CH2:12][CH3:13])[N:7]([CH2:14][C:15]3[CH:16]=[CH:17][C:18]([C:21]4[C:22]([C:27]([OH:29])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=4)=[CH:19][CH:20]=3)[C:6]=2[CH:5]=[C:4]([C:30]2[N:34]([CH3:35])[C:33]3[CH:36]=[CH:37][CH:38]=[CH:39][C:32]=3[N:31]=2)[CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 65999Telmisartan

Product 1

HCID 11956638Telmisartan Hydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10 g of telmisartan are suspended in 70 ml of methanol in a round-bottom flask equipped with magnetic stirrer, condenser and under nitrogen atmosphere. The solution is added with 2.0 ml of a 37% HCl aqueous solution and the mixture is heated under reflux, then cooled to room temperature. The resulting precipitate is filtered and dried under vacuum at 55° C. to obtain 7.5 g of telmisartan hydrochloride.

Workup

  1. customequipped with magnetic stirrer, condenser and under nitrogen atmosphere
  2. temperaturethe mixture is heated
  3. temperatureunder reflux
  4. filtrationThe resulting precipitate is filtered
  5. customdried under vacuum at 55° C.

Sources & evidence

ORD record
ord-850229d9d6234a3bb62959ac022dad54
Source dataset
uspto-grants-2010_04
Patent number
US07692027B2

Reaction notes

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