反应详情

The solution of ethyl 2-morpholinoacetate (0.73 g, 4.24 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated on vacuum pump and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 60% yield (0.37 g). LC-MS (ESI): Calculated mass: 145.1; Observed mass 146.3 [M+H]+ (rt: 0.28 min).

1. concentrationThe mixture was concentrated on vacuum pump
2. customquenched
3. extractionextracted as in Intermediate Example 15(b)
4. distillationThe solvent was distilled off
5. customto afford the product in 60% yield (0.37 g)
6. customObserved mass 146.3 [M+H]+ (rt: 0.28 min)