Hydrogen iodide → 2-Methylquinazolin-8-ol

HRID 640783Notes

Reaction equation

HRID 640783 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([OH:12])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:13])[N:3]=1.I>>[OH:12][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:6]=1[N:5]=[C:4]([CH3:13])[N:3]=[CH:2]2

Participants

3

Reactant 2

HCID 24841Hydrogen iodideHCID 534265274-Chloro-2-methylquinazolin-8-ol

Product 1

HCID 106070502-Methylquinazolin-8-ol

Procedure

4-Chloro-8-hydroxy-2-methyl-quinazoline (0.01 mol) was treated with hydriodic acid (100 mL; freshly distilled from red phosphorus) according to the method described6 in the literature. This provided 8-hydroxy-2-methyl-quinazoline (A3) as a solid.

Workup

  1. distillationfreshly distilled from red phosphorus)

Sources & evidence

ORD record
ord-237b429ea6134b248081cd7d1c2d1e1f
Source dataset
uspto-grants-2010_04
Patent number
US07692011B2

Reaction notes

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