Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Bromopropane → HCID 59256694, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Bromopropane | HCID 6358 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 반응물 | 4-Chloro-2-methylquinazolin-8-ol | HCID 53426527 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | HCID 59256694 | HCID 59256694 | — |
반응 단계
2-Bromopropane (9 mmol) was added to a stirred mixture of 4-chloro-8-hydroxy-2-methyl-quinazoline (A2) (6 mmol), K2CO3 (24 mmol) and DMSO (20 mL). After 16 h at RT, saturated NH4Cl (20 mL) was added and the mixture extracted with dichloromethane (20 mL×3). The extracts were combined and concentrated. Diethyl ether (100 mL) was added to the residue and the resulting mixture washed successively with 2 N NaOH, H2O and brine, and dried (Na2SO4). Solvent removal afforded 4-chloro-8-isopropoxy-2-methyl-quinazoline (35) as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07692011B2 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-c359dcf47a4a4925873e0e6e75be58b5 |
| 출처 메모 | uspto-grants-2010_04 |