反应详情

2-Bromopropane (9 mmol) was added to a stirred mixture of 4-chloro-8-hydroxy-2-methyl-quinazoline (A2) (6 mmol), K2CO3 (24 mmol) and DMSO (20 mL). After 16 h at RT, saturated NH4Cl (20 mL) was added and the mixture extracted with dichloromethane (20 mL×3). The extracts were combined and concentrated. Diethyl ether (100 mL) was added to the residue and the resulting mixture washed successively with 2 N NaOH, H2O and brine, and dried (Na2SO4). Solvent removal afforded 4-chloro-8-isopropoxy-2-methyl-quinazoline (35) as a solid.

1. extractionthe mixture extracted with dichloromethane (20 mL×3)
2. concentrationconcentrated
3. additionDiethyl ether (100 mL) was added to the residue
4. washthe resulting mixture washed successively with 2 N NaOH, H2O and brine
5. dry with materialdried (Na2SO4)
6. customSolvent removal