Iodine chloride → HCID 59256695, compound

HRID 640788Notes

Reaction equation

HRID 640788 reaction equation
[Cl:1][C:2]1[CH:11]=[CH:10][C:9]([OH:12])=[C:8]2[C:3]=1[CH:4]=[N:5][CH:6]=[N:7]2.[I:13]Cl>Cl>[Cl:1][C:2]1[CH:11]=[C:10]([I:13])[C:9]([OH:12])=[C:8]2[C:3]=1[CH:4]=[N:5][CH:6]=[N:7]2

Participants

4

Reactant 2

HCID 24640Iodine chlorideHCID 59256643HCID 59256643, compound

Product 1

HCID 59256695HCID 59256695, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

5-Chloro-8-hydroxy-quinazoline (10 mmol) was added to a stirred solution of ICl (12 mmol) in concentrated HCl (10 mL).8 After 5 min, the precipitate was isolated via filtration, washed successively with H2O, saturated sodium thiosulfate and H2O, and dried. This provided 5-chloro-8-hydroxy-7-iodo-quinazoline (A53) as a solid.

Workup

  1. customthe precipitate was isolated via filtration
  2. washwashed successively with H2O, saturated sodium thiosulfate and H2O
  3. customdried

Sources & evidence

ORD record
ord-2dc10d0032ba4301a936ba10feaf4dfc
Source dataset
uspto-grants-2010_04
Patent number
US07692011B2

Reaction notes

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