Ammonium Chloride → HCID 89500232, compound

Participants

Reaction Steps

To a solution of N-(5-(4-bromo-2-nitrophenylamino)-2′,4′-difluorobiphenyl-3-yl)acetamide (3.2 g, 6.92 mmol) in THF (30 ml) were added a solution of ammonium chloride (3.7 g, 69.22 mmol, 10 eq.) in water (15 ml) and zinc (4.53 g, 69.22 mmol, 10 eq.). The mixture was stirred at RT for 6 h and filtered. The filtrate was diluted with water and extracted as in Example 1(d). The solvent was distilled off under reduced pressure to afford the product in 87% yield (2.6 g).

Provenance & Evidence