反应详情

To a solution of N-(5-(4-bromo-2-nitrophenylamino)-2′,4′-difluorobiphenyl-3-yl)acetamide (3.2 g, 6.92 mmol) in THF (30 ml) were added a solution of ammonium chloride (3.7 g, 69.22 mmol, 10 eq.) in water (15 ml) and zinc (4.53 g, 69.22 mmol, 10 eq.). The mixture was stirred at RT for 6 h and filtered. The filtrate was diluted with water and extracted as in Example 1(d). The solvent was distilled off under reduced pressure to afford the product in 87% yield (2.6 g).

1. filtrationfiltered
2. additionThe filtrate was diluted with water
3. extractionextracted as in Example 1(d)
4. distillationThe solvent was distilled off under reduced pressure
5. customto afford the product in 87% yield (2.6 g)