反应详情

温度

90 °C

To a solution of the compound of Example 44 (400 mg, 0.77 mmol) in ethanol (20 ml) was added aqueous solution of NaOH (385 mg, 9.63 mmol, 12.5 eq.) and the mixture was heated at 90° C. for 3 h. The mixture was quenched and extracted as in Example 1(d). The solvent was distilled off to give the product in 38% yield (140 mg).

1. customThe mixture was quenched
2. extractionextracted as in Example 1(d)
3. distillationThe solvent was distilled off
4. customto give the product in 38% yield (140 mg)