Sodium Hydroxide → 4-(4-(1-(5-amino-2',4'-difluorobiphenyl-3-yl)-1H-benzo[d]imidazol-5-yl)-1H-1,2,3-triazol-1-yl)-2-methylbutan-2-ol

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Sodium Hydroxide	HCID 14798	—
Edukt	N-(2',4'-difluoro-5-(5-(1-(3-hydroxy-3-methylbutyl)-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-yl)acetamide	HCID 89501332	—
Lösungsmittel	Ethanol	HCID 702	—
Produkt	4-(4-(1-(5-amino-2',4'-difluorobiphenyl-3-yl)-1H-benzo[d]imidazol-5-yl)-1H-1,2,3-triazol-1-yl)-2-methylbutan-2-ol	HCID 117777938	38%

Reaktionsbedingungen

Temperatur	90 °C

Reaktionsschritte

To a solution of the compound of Example 44 (400 mg, 0.77 mmol) in ethanol (20 ml) was added aqueous solution of NaOH (385 mg, 9.63 mmol, 12.5 eq.) and the mixture was heated at 90° C. for 3 h. The mixture was quenched and extracted as in Example 1(d). The solvent was distilled off to give the product in 38% yield (140 mg).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09447091B2
Quelldatensatz	uspto-grants-2016_09
ORD ID	ord-8243a5016ee2402c8fa11bd45173a00b
Quellennotiz	uspto-grants-2016_09