反应详情

温度

65 °C

A small screw cap test tube was charged with 5-Ethyl-1-methyl-1H-pyrazole-3-carboxylic acid [3-(3-hydroxymethylene-2-oxo-2,3-dihydro-1H-indole-6-carbonyl)-phenyl]-amide (prepared below, 61 mg, 0.1465 mmol) and THF (2.0 mL). To the resulting solution was added 4-(4-methyl-piperazin-1-yl)-phenylamine (27.7 mg, 0.145 mmol), and the mixture was stirred for 24 h at 65° C. Subsequently, the reaction mixture was cooled to room temperature and concentrated in vacuo. The solid residue was recrystallized with 5 mL of i-prOH affording the title compound in 12% yield (0.010 g, 0.017 mmol).

1. customA small screw cap test tube
2. temperatureSubsequently, the reaction mixture was cooled to room temperature
3. concentrationconcentrated in vacuo
4. customThe solid residue was recrystallized with 5 mL