HCID 66646174, compound → HCID 11350505, compound

HRID 641147Notes

Reaction equation

HRID 641147 reaction equation
C(OC(=O)[NH:7][C@:8]([CH2:26][O:27][P:28]([O:35]C(C)(C)C)([O:30]C(C)(C)C)=[O:29])([CH3:25])[CH2:9][CH2:10][C:11]1[CH:16]=[C:15]([Cl:17])[C:14]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[C:13]([Cl:24])[CH:12]=1)(C)(C)C>C(O)(=O)C.Cl>[NH2:7][C@:8]([CH3:25])([CH2:9][CH2:10][C:11]1[CH:16]=[C:15]([Cl:17])[C:14]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[C:13]([Cl:24])[CH:12]=1)[CH2:26][O:27][P:28](=[O:29])([OH:35])[OH:30]

Participants

4

Reactant 1

HCID 66646174HCID 66646174, compound

Product 1

HCID 11350505HCID 11350505, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 313Hydrochloric AcidSolvent

Procedure

A solution of [(R)-1-(Di-tert-butoxy-phosphoryloxymethyl)-3-(3,5-dichloro-4-pentyloxy-phenyl)-1-methyl-propyl]-carbamic acid tert-butyl ester (43 mg, 0.07 mmol) in acetic acid (0.4 ml) and conc. HCl (0.042 ml) is left standing at RT for 4 h. After evaporation of the solvent, the oily residue is treated with Et2O to yield the title compound as a white precipitate which is filtered off. MS (ESI−): m/z =413/415 (M−H−).

Workup

  1. customAfter evaporation of the solvent
  2. additionthe oily residue is treated with Et2O

Sources & evidence

ORD record
ord-35808697a7a74e6980890f674f7b25a8
Source dataset
uspto-grants-2010_04
Patent number
US07696184B2

Reaction notes

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