HCID 66646129, compound → HCID 11371650, compound

HRID 641149Notes

Reaction equation

HRID 641149 reaction equation
C(OC(=O)[NH:7][C@:8]([CH2:26][OH:27])([CH3:25])[CH2:9][CH2:10][C:11]1[CH:16]=[C:15]([F:17])[C:14]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[C:13]([Cl:24])[CH:12]=1)(C)(C)C>O1CCOCC1>[ClH:24].[NH2:7][C@:8]([CH3:25])([CH2:9][CH2:10][C:11]1[CH:16]=[C:15]([F:17])[C:14]([O:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[C:13]([Cl:24])[CH:12]=1)[CH2:26][OH:27]

Participants

3

Reactant 1

HCID 66646129HCID 66646129, compound

Product 1

HCID 11371650HCID 11371650, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

[(R)-3-(3-Chloro-5-fluoro-4-pentyloxy-phenyl)-1-hydroxymethyl-1-methyl-propyl]-carbamic acid tert-butyl ester (10 mg) is dissolved in dioxane containing 4 M HCl (0.5 ml). After stirring at RT for 18 h the product is precipitated by the addition of Et2O to yield the title compound as white solid. MS (ESI+): m/z=319 (MH+).

Workup

  1. customis precipitated by the addition of Et2O

Sources & evidence

ORD record
ord-b7efea3d10c049c08fbc1b21d4a364fb
Source dataset
uspto-grants-2010_04
Patent number
US07696184B2

Reaction notes

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