Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-[(1R)-1-Aminoethyl]-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzamide--hydrogen chloride (1/2) | HCID 20601328 | — |
| Solvent | Water | HCID 962 | — |
| Product | Y-39983 hydrochloride | HCID 11507964 | — |
Reaction Steps
(R)-(+)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)-4-(1-aminoethyl)benzamide dihydrochloride 3/2 hydrate (8.5 g) obtained in Reference Example 1 was dissolved in water (50 mL) and 1N—NaOH aqueous solution was added dropwise while stirring under ice-cooling. The precipitated crystals were collected by filtration and dried (warm air: 60° C., 10 hrs) to give a free base form (6.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07696194B2 |
|---|
| Source dataset | uspto-grants-2010_04 |
|---|
| ORD ID | ord-201590f6d3d74d9981bcdd36ab5ad0de |
|---|
| Source note | uspto-grants-2010_04 |
|---|
