反应详情

31.1 g (88.1 mmol) methyl 2-acetylamino-3-(4-benzyloxy-3,5-dimethyl-phenyl)-acrylate in 150 mL 1,4-dioxane were combined with 125 mL 4 M HCl, stirred for 7 h at reflux temperature and stirred overnight at RT. The precipitate was suction filtered, washed with water and dried at 45° C. in the vacuum drying cupboard.

1. temperatureat reflux temperature
2. stirringstirred overnight at RT
3. filtrationfiltered
4. washwashed with water
5. customdried at 45° C. in the vacuum
6. customdrying cupboard