反应详情

温度

45 °C

To a solution of N-(5-nitrobiphenyl-3-yl)acetamide (1.2 g, 4.68 mmol) in THF (10 ml) were added a solution of ammonium chloride (2 g, 37.4 mmol, 8 eq.) in water (2 ml) and zinc (2.36 g, 37.4 mmol, 8 eq.). The mixture was stirred at 45° C. for 2 h and filtered. The filtrate was diluted with water and extracted as in Example 1(d). The solvent was distilled off to afford the product in 94% yield (1 g).

1. filtrationfiltered
2. additionThe filtrate was diluted with water
3. extractionextracted as in Example 1(d)
4. distillationThe solvent was distilled off
5. customto afford the product in 94% yield (1 g)