Calcium Chloride → N-(5-amino-4'-methoxybiphenyl-3-yl)acetamide

Participants

Reaction Conditions

Reaction Steps

To a solution of N-(4′-methoxy-5-nitrobiphenyl-3-yl)acetamide (4 g, 13.98 mmol) in ethanol (50 ml) were added calcium chloride (3.1 g, 27.96 mmol, 2 eq.) and iron powder (1.45 g, 27.96 mmol, 2 eq.) and the mixture was heated at 100° C. for 2 h and filtered. The filtrate was diluted with water and extracted as in Example 1(d). The solvent was distilled off to afford the product in 87% yield (3.1 g).

Provenance & Evidence