Acetic Acid → HCID 57525652, compound

HRID 641356Notes

Reaction equation

HRID 641356 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[O:42])[CH2:11][N:12]1[C:21](=[O:22])[C:20]2[N:19]([CH2:23]/[CH:24]=[CH:25]/[CH3:26])[C:18]([N:27]3[CH2:32][CH2:31][CH2:30][C@@H:29]([NH:33][C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH2:28]3)=[N:17][C:16]=2[N:15]([CH3:41])[C:13]1=[O:14])([O-])=O.O.C(O)(=O)C>C(O)C.[Fe]>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10](=[O:42])[CH2:11][N:12]1[C:21](=[O:22])[C:20]2[N:19]([CH2:23]/[CH:24]=[CH:25]/[CH3:26])[C:18]([N:27]3[CH2:32][CH2:31][CH2:30][C@@H:29]([NH:33][C:34]([O:36][C:37]([CH3:39])([CH3:38])[CH3:40])=[O:35])[CH2:28]3)=[N:17][C:16]=2[N:15]([CH3:41])[C:13]1=[O:14]

Participants

6

Reactant 3

HCID 176Acetic AcidHCID 962WaterHCID 57525654HCID 57525654, compound

Product 1

HCID 57525652HCID 57525652, compound

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 702EthanolSolvent

Procedure

Prepared by reduction of 6.34 g 1-[2-(2-nitro-phenyl)-2-oxo-ethyl]-3-methyl-7-((E)-2-buten-1-yl)-8-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine with 5.15 g iron powder in a mixture of 260 ml of ethanol, 85 ml of water and 33 ml glacial acetic acid at reflux temperature.

Workup

  1. temperatureat reflux temperature

Sources & evidence

ORD record
ord-51375e83286540ec9977ec0d98128783
Source dataset
uspto-grants-2010_04
Patent number
US07696212B2

Reaction notes

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