反应详情

A mixture of 20% NaOH (5 ml) and the compound of Example 171 (0.9 g, 2.12 mmol) in 25 ml of ethanol was heated at 90° C. for 2 h. The mixture was diluted with ethyl acetate (100 ml) and the organic layer was washed with water (50 ml) and brine (25 ml). The solvent was distilled off and the residue was purified by column chromatography over silica gel to afford the compound in 78% yield (0.7 g).

1. washthe organic layer was washed with water (50 ml) and brine (25 ml)
2. distillationThe solvent was distilled off
3. customthe residue was purified by column chromatography over silica gel
4. customto afford the compound in 78% yield (0.7 g)