Sodium Hydroxide → HCID 117777695, compound

Participants

Role	Name	HCID	Charge
Reactant	Sodium Hydroxide	HCID 14798	—
Reactant	N-(5-(5-(1H-pyrazol-1-yl)-1H-benzo[d]imidazol-1-yl)-2',6'-difluorobiphenyl-3-yl)acetamide	HCID 89501165	—
Solvent	Ethanol	HCID 702	—
Product	HCID 117777695	HCID 117777695	89%

Reaction Conditions

Temperature	100 °C

Reaction Steps

To a solution of the compound of Example 152 (2.1 g, 4.895 mmol) in ethanol (50 ml) was added 10% aqueous solution of NaOH (10 ml) and the mixture was heated at 100° C. for 2 h. The mixture was quenched and extracted as in Example 1(d). The solvent was distilled off to afford the product in 89% yield (1.6 g).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09447091B2
Source dataset	uspto-grants-2016_09
ORD ID	ord-d19410134990473089a3014f31ca66c3
Source note	uspto-grants-2016_09