Methylamine → HCID 57440303, compound

HRID 641554Notes

Reaction equation

[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:14][CH2:13][C:12]2[CH:15]=[CH:16][C:17]([O:19][C:20]3[CH:21]=[C:22]([CH:26]=[CH:27][C:28]=3[O:29][CH3:30])[C:23](O)=[O:24])=[CH:18][C:11]=2[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3].[CH3:31][NH2:32]>>[CH3:31][NH:32][C:23]([C:22]1[CH:26]=[CH:27][C:28]([O:29][CH3:30])=[C:20]([O:19][C:17]2[CH:16]=[CH:15][C:12]3[CH2:13][CH2:14][N:8]([C:6]([O:5][C:2]([CH3:4])([CH3:3])[CH3:1])=[O:7])[CH2:9][CH2:10][C:11]=3[CH:18]=2)[CH:21]=1)=[O:24]

Participants

Reactant 2

HCID 6329Methylamine

HCID 57440302HCID 57440302, compound

Product 1

HCID 57440303HCID 57440303, compound

Procedure

The title compound was prepared from 3-[(3-{[(1,1-dimethylethyl)oxy]carbonyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-4-(methyloxy)benzoic acid (E266, Step 2) and methylamine using the method of Example 264, Step 5; MS (ES+) m/e 327 [(M+H)—CO2tBu]+.

Sources & evidence

ORD record: ord-9f1507f36e5f4aa59c1cc70af974ba92
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07696193B2

Reaction notes

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