反应详情

温度

150 °C

(1S,2R,4R)-N-[2-(4-Bromo-benzenesulfonylmethyl)-4-(isopropyl-methyl-amino)-cyclohexyl]-2-(4-trifluoromethyl-1H-benzoimidazol-2-yl)-acetamide, Example 3, was dissolved in THF (1 ml) prior to the addition of propyl zinc bromide (0.32 ml), Pd(PPh3)4 (3 mg). The mixture was stirred under microwave conditions (150° C.) for 5 min. After cooling, the crude reaction was filtered and the filtrate was concentrated. Reverse phase HPLC purification (gradient elution, water/acetonitrile/TFA) of the resulting residue provided the two fractions, one of which contained the title compound (8 mg). MS found: (M+H)+=594.5

1. temperatureAfter cooling
2. customthe crude reaction
3. filtrationwas filtered
4. concentrationthe filtrate was concentrated
5. customReverse phase HPLC purification (gradient elution, water/acetonitrile/TFA) of the resulting residue
6. customprovided the two fractions, one of which