Potassium Carbonate → HCID 59258961, compound

HRID 641668Notes

Reaction equation

HRID 641668 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([CH3:23])[C:5]2[CH:11]=[C:10]([C:12]#[C:13][Si](C)(C)C)[C:9](=[O:18])[N:8]([CH:19]3[CH2:22][CH2:21][CH2:20]3)[C:6]=2[N:7]=1.C([O-])([O-])=O.[K+].[K+]>CO>[NH2:1][C:2]1[N:3]=[C:4]([CH3:23])[C:5]2[CH:11]=[C:10]([C:12]#[CH:13])[C:9](=[O:18])[N:8]([CH:19]3[CH2:22][CH2:21][CH2:20]3)[C:6]=2[N:7]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 59258895HCID 59258895, compound

Product 1

HCID 59258961HCID 59258961, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a stirred solution of 2-amino-8-cyclobutyl-4-methyl-6-(2-(trimethylsilyl)ethynyl)pyrido[2,3-d]pyrimidin-7(8H)-one (105 mg, 0.322 mmol) in MeOH (7 mL) was added K2CO3 (50 mg, 0.36 mmol) and the mixture was stirred for 5 h. LC-MS indicated complete conversion. Solvent was evaporated and the residue was purified by flash chromatography, using CHCl3, to give the title compound (81 mg, 99%).

Workup

  1. customSolvent was evaporated
  2. customthe residue was purified by flash chromatography

Sources & evidence

ORD record
ord-183fa07d074a4580b75cf5f14240f819
Source dataset
uspto-grants-2010_04
Patent number
US07696213B2

Reaction notes

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