Ethanol → HCID 178496607, compound

HRID 641676Notes

Reaction equation

HRID 641676 reaction equation
[Br:1][C:2]1[C:3]([NH:16][C@H:17]2[CH2:22][CH2:21][C@H:20]([O:23][CH3:24])[CH2:19][CH2:18]2)=[N:4][C:5]([N:9]2C(C)=CC=C2C)=[N:6][C:7]=1[CH3:8].Cl.NO.C(O)C>O>[Br:1][C:2]1[C:3]([NH:16][C@H:17]2[CH2:22][CH2:21][C@H:20]([O:23][CH3:24])[CH2:19][CH2:18]2)=[N:4][C:5]([NH2:9])=[N:6][C:7]=1[CH3:8]

Participants

5

Reactant 3

HCID 702EthanolHCID 443297Hydroxyamine hydrochloride2×HCID 178496606HCID 178496606, compound

Product 1

HCID 178496607HCID 178496607, compoundYield 89.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 5-bromo-2-(2,5-dimethyl-1H-pyrrol-1-yl)-N-(trans-4-methoxycyclohexyl)-6-methylpyrimidin-4-amine (1.07 g, 2.72 mmol) and hydroxylamine hydrochloride (945 mg, 13.6 mmol) in 10:1 ethanol:water (27.5 mL) was heated to reflux for 7 hours, then room temperature overnight. Another 0.5 eq of hydroxylamine hydrochloride was added and the solution was refluxed for another 4 hours, then cooled to room temperature and concentrated. The crude product was purified by flash chromatography eluting with chloroform/methanol (0.5-3%) to afford 5-bromo-N4-(trans-4-methoxycyclohexyl)-6-methylpyrimidine-2,4-diamine (767 mg, 89%).

Workup

  1. temperatureto reflux for 7 hours
  2. customroom temperature overnight
  3. temperaturethe solution was refluxed for another 4 hours
  4. concentrationconcentrated
  5. customThe crude product was purified by flash chromatography
  6. washeluting with chloroform/methanol (0.5-3%)

Sources & evidence

ORD record
ord-f7962fee49ba4e6e8cf26ff3921a08cf
Source dataset
uspto-grants-2010_04
Patent number
US07696213B2

Reaction notes

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