反应详情

To a solution of N-(3-(3-fluoropyridin-2-yl)-5-nitrophenyl)acetamide (5 g, 18.18 mmol) in THF (50 ml), Zn (11.8 g, 181.18 mmol) was added followed by slow addition of solution of NH4Cl (9.7 g, 181.18 mmol) in 20 ml water. The mixture was stirred at RT for 1 h. The mixture was filtered through celite and bed washed with ethyl acetate. The mixture was diluted with ethyl acetate and washed with water and brine solution, dried over sodium sulphate and distilled to give the product in 90% yield (4.2 g). LC-MS (ESI): Calculated mass: 245; Observed mass: 246.1 [M+H]+ (rt: 0.21 min).

1. filtrationThe mixture was filtered through celite and bed
2. washwashed with ethyl acetate
3. additionThe mixture was diluted with ethyl acetate
4. washwashed with water and brine solution
5. dry with materialdried over sodium sulphate
6. distillationdistilled
7. customto give the product in 90% yield (4.2 g)
8. custom246.1 [M+H]+ (rt: 0.21 min)