Ammonia → HCID 135510694, compound

HRID 641753Notes

Reaction equation

HRID 641753 reaction equation
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([NH:19][C:20]3[CH:25]=[C:24]([O:26][CH3:27])[CH:23]=[CH:22][C:21]=3[Cl:28])=[N:14][CH:15]=[N:16]2)=[C:11]([O:29][CH:30]2[CH2:34][CH2:33][O:32][CH2:31]2)[CH:10]=1)C1C=CC=CC=1.FC(F)(F)C(O)=O.N>C(Cl)Cl>[Cl:28][C:21]1[CH:22]=[CH:23][C:24]([O:26][CH3:27])=[CH:25][C:20]=1[NH:19][C:13]1[C:12]2[C:17](=[CH:18][C:9]([OH:8])=[CH:10][C:11]=2[O:29][CH:30]2[CH2:34][CH2:33][O:32][CH2:31]2)[N:16]=[CH:15][N:14]=1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 6422Trifluoroacetic acidHCID 11974942HCID 11974942, compound

Product 1

HCID 135510694HCID 135510694, compoundYield 148.5%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Using an analogous procedure to that described in Example 20, 7-benzyloxy-4-(2-chloro-5-methoxyanilino)-5-tetrahydrofuran-3-yloxyquinazoline (0.39 g) was reacted with trifluoroacetic acid (2.5 ml). The reaction mixture was evaporated and the residue was triturated under diethyl ether. The precipitate was isolated and the solid was dissolved in a mixture of methylene chloride and a saturated methanolic ammonia solution. The mixture was evaporated and the residue was purified by column chromatography on silica using a 97:3 mixture of methylene chloride and methanol as eluent. There was thus obtained the title compound (0.47 g); NMR Spectrum: (DMSOd6 and CF3CO2D) 2.2-2.3 (m, 1M, 2.3-2.5 (m, 1H), 3.8 (s, 3H), 3.75-3.9 (m, 1H), 3.9-4.0 (m, 2H), 4.2 (d, 1H), 5.5 (m, 1H), 6.8 (s, 1H), 6.92 (s, 1H), 7.02 (m, 1H), 7.55 (d, 1H), 7.6 (d, 1H), 8.85 (s, 1H); Mass Spectrum: M+H+ 388 and 390.

Workup

  1. customThe reaction mixture was evaporated
  2. customthe residue was triturated under diethyl ether
  3. customThe precipitate was isolated
  4. customThe mixture was evaporated
  5. customthe residue was purified by column chromatography on silica using
  6. additiona 97:3 mixture of methylene chloride and methanol as eluent

Sources & evidence

ORD record
ord-7cdc81c7c1e848bb878fe1845db3132d
Source dataset
uspto-grants-2010_04
Patent number
US07696214B2

Reaction notes

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