Hydrochloric Acid → HCID 22140708, compound

HRID 641759Notes

Reaction equation

[ClH:1].Cl.C(OC([N:10]1[CH2:15][CH2:14][CH:13]([O:16][C:17]2[CH:26]=[CH:25][CH:24]=[C:23]3[C:18]=2[C:19]([NH:27][C:28]2[C:33]([Cl:34])=[CH:32][CH:31]=[C:30]4[O:35][CH2:36][O:37][C:29]=24)=[N:20][CH:21]=[N:22]3)[CH2:12][CH2:11]1)=O)(C)(C)C.Cl>>[ClH:34].[ClH:1].[Cl:34][C:33]1[C:28]([NH:27][C:19]2[C:18]3[C:23](=[CH:24][CH:25]=[CH:26][C:17]=3[O:16][CH:13]3[CH2:12][CH2:11][NH:10][CH2:15][CH2:14]3)[N:22]=[CH:21][N:20]=2)=[C:29]2[O:37][CH2:36][O:35][C:30]2=[CH:31][CH:32]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 22140756HCID 22140756, compound

Product 1

HCID 22140708HCID 22140708, compoundYield 195.7%

Procedure

Using an analogous procedure to that described in Example 31, 5-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(6-chloro-2,3-methylenedioxyanilino)quinazoline dihydrochloride (0.14 g) was reacted with hydrogen chloride to give the title compound (0.113 g); NMR Spectrum: (DMSOd6) 2.15-2.34 (m, 4H), 3.15 (m, 2H), 3.3 (m, 2H), 5.17 (m, 1H), 6.17 (s, 2H), 7.07 (d, 1H), 7.16 (d, 1H), 7.58 (m, 1H), 8.06 (m, 1H), 8.88 (s, 1H), 9.14 (br s, 1H), 9.32 (br s, 1H), 10.28 (s, 1H); Mass Spectrum: M+H+ 399 and 401.

Sources & evidence

ORD record: ord-ac7d526b812247ae9a42b1cfbe29a4c0
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07696214B2

Reaction notes

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