Carbon Tetrachloride → 4-Chloro-5-fluoroquinazoline

HRID 641768Notes

Reaction equation

HRID 641768 reaction equation
[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4](=O)[NH:5][CH:6]=[N:7]2.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.C(Cl)(Cl)(Cl)[Cl:33]>>[F:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[C:4]([Cl:33])=[N:5][CH:6]=[N:7]2

Participants

4

Reactant 3

HCID 5943Carbon TetrachlorideHCID 11776TriphenylphosphineHCID 1354959305-Fluoroquinazolin-4-ol

Product 1

HCID 119744454-Chloro-5-fluoroquinazoline

Procedure

Thus, 5-fluoro-3,4-dihydroquinazolin-4-one (2 g) was reacted with triphenylphosphine and carbon tetrachloride to give 5-fluoro-4-chloroquinazoline (1.34 g); NMR Spectrum: (CDCl3) 7.47.5 (m, 1H), 7.9-8.0 (m, 2H), 9.1 (s, 1H); and

Sources & evidence

ORD record
ord-ddb702d35dc94e899541f71144714b95
Source dataset
uspto-grants-2010_04
Patent number
US07696214B2

Reaction notes

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