Formic Acid → HCID 178522008, compound

HRID 641787Notes

Reaction equation

HRID 641787 reaction equation
Cl[C:2]1[C:7]2[NH:8][C:9]([CH2:11][C:12]3[CH:17]=[CH:16][C:15]([NH:18][C:19]([NH:21][C:22]4[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:25]=[CH:24][C:23]=4[F:32])=[O:20])=[CH:14][CH:13]=3)=[N:10][C:6]=2[CH:5]=[CH:4][N:3]=1.C(O)=[O:34]>>[OH:34][C:2]1[C:7]2[NH:8][C:9]([CH2:11][C:12]3[CH:17]=[CH:16][C:15]([NH:18][C:19]([NH:21][C:22]4[CH:27]=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:25]=[CH:24][C:23]=4[F:32])=[O:20])=[CH:14][CH:13]=3)=[N:10][C:6]=2[CH:5]=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 178522007HCID 178522007, compound

Product 1

HCID 178522008HCID 178522008, compound

Procedure

2.4 A solution of 50 mg of “A2” in 1 ml of formic acid (98-100%) is refluxed for 8 hours and subsequently purified via an RP18 column, giving 3 mg of 1-[4-(4-hydroxy-3H-imidazo[4,5-c]pyridin-2-ylmethyl)phenyl]-3-(2-fluoro-5-trifluoromethylphenyl)urea (“A3”), Rf 2.88.

Workup

  1. customsubsequently purified via an RP18 column

Sources & evidence

ORD record
ord-4c3f601eac454f488368093faf222299
Source dataset
uspto-grants-2010_04
Patent number
US07696224B2

Reaction notes

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