Benzoyl isothiocyanate → HCID 59259123, compound

HRID 641828Notes

Reaction equation

[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]([C:12]2[CH:17]=[C:16]([O:18][CH2:19][C:20]#[CH:21])[CH:15]=[CH:14][C:13]=2[NH:22][CH2:23][C:24]2[N:25]=[N:26][N:27]([CH2:29][CH2:30][O:31][CH3:32])[N:28]=2)=O)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].C([N:41]=[C:42]=[S:43])(=O)C1C=CC=CC=1>>[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:12]3[C:13](=[CH:14][CH:15]=[C:16]([O:18][CH2:19][C:20]#[CH:21])[CH:17]=3)[N:22]([CH2:23][C:24]3[N:25]=[N:26][N:27]([CH2:29][CH2:30][O:31][CH3:32])[N:28]=3)[C:42](=[S:43])[N:41]=2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 68284Benzoyl isothiocyanate

HCID 59259086HCID 59259086, compound

Product 1

HCID 59259123HCID 59259123, compound

Procedure

The title compound (red foam) is prepared from (4-isopropyl-phenyl)-(2-{[2-(2-methoxy-ethyl)-2H-tetrazol-5-ylmethyl]-amino}-5-prop-2-ynyloxy-phenyl)-methanone and benzoylisothiocyanate as described for the preparation of example 111.

Workup

customas described for the preparation of example 111

Sources & evidence

ORD record: ord-140cfbf27aaf41c88b0e2819d4fc30de
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07696216B2

Reaction notes

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