反应详情

温度

100 °C

To a solution of 1.0 g (4.76 mmol) 3-iodothiophene in 5 ml ethylene glycol is added 109 mg (1.71 mmol) copper powder, 114 mg (0.714 mmol) copper(II)sulphate and 151 mg (19.0 mmol) lithium hydride. The reaction mixture is heated overnight in a sealed flask at 100° C. The reaction mixture is filtered through Celite and evaporated. The resulting oil is then filtered through a 50 g silica pad and eluted with ethyl acetate/hexanes (7:3) to give after evaporation 750 mg of an orange liquid, which is used without purification directly in the next reaction.

1. filtrationThe reaction mixture is filtered through Celite
2. customevaporated
3. filtrationThe resulting oil is then filtered through a 50 g silica pad
4. washeluted with ethyl acetate/hexanes (7:3)
5. customto give
6. customafter evaporation 750 mg of an orange liquid, which
7. customis used without purification directly in the next reaction