反应详情

Using an analogous procedure to that described paragraph (B) in the portion of Example 1 which is concerned with the preparation of starting material N-ethylpiperazine was reacted with methyl 3-(6-bromo-4-oxoquinazolin-3(4H)-yl)-4-methylbenzoate to give methyl 4-methyl-3-[6-(4-ethylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]benzoate; NMR Spectrum: (DMSOd6) 1.05 (t, 3H), 2.17 (s, 3H), 2.40 (m, 2H), 2.53 (m, 4H), 3.29 (m, 4H), 3.87 (s, 3H), 7.48 (s, 1H), 7.63 (m, 3H), 7.97 (s, 1H), 8.02 (d, 1H), 8.10 (d, 1H); Mass Spectrum: M+H+ 407.