1-Ethylpiperazine → methyl 3-[8-cyano-6-(4-ethylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]-4-methylbenzoate

HRID 641971Notes

Reaction equation

HRID 641971 reaction equation
[CH2:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)[CH3:2].[C:9]([C:11]1[CH:12]=[C:13](I)[CH:14]=[C:15]2[C:20]=1[N:19]=[CH:18][N:17]([C:21]1[CH:22]=[C:23]([CH:28]=[CH:29][C:30]=1[CH3:31])[C:24]([O:26][CH3:27])=[O:25])[C:16]2=[O:32])#[N:10]>>[C:9]([C:11]1[CH:12]=[C:13]([N:6]2[CH2:7][CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][CH2:5]2)[CH:14]=[C:15]2[C:20]=1[N:19]=[CH:18][N:17]([C:21]1[CH:22]=[C:23]([CH:28]=[CH:29][C:30]=1[CH3:31])[C:24]([O:26][CH3:27])=[O:25])[C:16]2=[O:32])#[N:10]

Participants

3

Reactant 2

HCID 791961-EthylpiperazineHCID 68603006methyl 3-(8-cyano-6-iodo-4-oxoquinazolin-3(4H)-yl)-4-methylbenzoate

Product 1

HCID 68603389methyl 3-[8-cyano-6-(4-ethylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]-4-methylbenzoate

Procedure

Using an analogous procedure to that described paragraph (B) in the portion of Example 1 which is concerned with the preparation of starting material N-ethyl piperazine was reacted with methyl 3-(8-cyano-6-iodo-4-oxoquinazolin-3(4H)-yl)-4-methylbenzoate to give methyl 3-[8-cyano-6-(4-ethylpiperazin-1-yl)-4-oxoquinazolin-3(4H)-yl]-4-methylbenzoate; Mass Spectrum: M+H+ 432.

Sources & evidence

ORD record
ord-c40424ad1d59415292c821da4d4252d9
Source dataset
uspto-grants-2010_04
Patent number
US07696215B2

Reaction notes

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