反应详情

Into a suspension of methyl 4-{[2-(5-iodo-2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazino]carbonyl}benzoate (80 mg, 0.18 mmol) in THF (5 mL) was added NaOH (0.2 M, 2.5 mL). The resulting solution was stirred at rt for 5 hrs and quenched with HCl (1N, 2 mL) and water (5 mL). A yellow solid precipitated out. Filtration, washing with water (2×1 mL) and drying under vacuo at rt for 72 hrs to give the tilte compound as a yellow powder (58 mg, 75%) in 98.6% purity by HPLC (MaxPlot detection between 230 and 400 nm).

1. customquenched with HCl (1N, 2 mL) and water (5 mL)
2. customA yellow solid precipitated out
3. filtrationFiltration
4. washwashing with water (2×1 mL)
5. customdrying under vacuo at rt for 72 hrs