Hydrazine hydrate (1:1) → HCID 68408760, compound

HRID 642108Notes

Reaction equation

HRID 642108 reaction equation
C[O:2][C:3](=O)[C:4]([NH:6][C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10]([O:12][CH3:13])=[O:11])=[O:5].O.[NH2:19][NH2:20]>CO>[NH:19]([C:3](=[O:2])[C:4]([NH:6][C:7]1[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=1)[C:10]([O:12][CH3:13])=[O:11])=[O:5])[NH2:20]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 68409078HCID 68409078, compound

Product 1

HCID 68408760HCID 68408760, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of methyl 3-{[methoxy(oxo)acetyl]amino}benzoate (100 mg, 0.42 mmol) in MeOH (8 mL) was added hydrazine hydrate (0.2 mL). After stirring for 0.5 h at rt, the reaction mixture was filtered. Washing with MeOH (2×1 mL) and water (3×1 mL) and drying under vacuo at 70° C. for 2 hrs gave 82 mg of the title compound (82%) as a white solid in 97.1% purity by HPLC (MaxPlot detection between 230 and 400 nm).

Workup

  1. filtrationthe reaction mixture was filtered
  2. washWashing with MeOH (2×1 mL) and water (3×1 mL)
  3. customdrying under vacuo at 70° C. for 2 hrs

Sources & evidence

ORD record
ord-ee9ac20761d9446fb40c97bc7bcddf95
Source dataset
uspto-grants-2010_04
Patent number
US07696231B2

Reaction notes

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