Hydrazine hydrate (1:1) → HCID 178514455, compound

HRID 642129Notes

Reaction equation

HRID 642129 reaction equation
[N:1]1[NH:2][N:3]=[N:4][C:5]=1[C:6]1[CH:17]=[CH:16][C:9]([O:10][CH2:11][C:12](OC)=[O:13])=[CH:8][CH:7]=1.O.[NH2:19][NH2:20]>CO>[NH:4]1[C:5]([C:6]2[CH:17]=[CH:16][C:9]([O:10][CH2:11][C:12]([NH:19][NH2:20])=[O:13])=[CH:8][CH:7]=2)=[N:1][N:2]=[N:3]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 59205718HCID 59205718, compound

Product 1

HCID 178514455HCID 178514455, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of methyl [4-(2H-tetrazol-5-yl)phenoxy]acetate (1.10 g, 4.06 mmol) in MeOH (30 mL) was added hydrazine hydrate (2.0 mL). After stirring for 90 min at rt, the reaction mixture was evaporated off. The residue was taken up with MeOH (10 mL) and a white solid precipitated out. Filtration, washing with MeOH (2×3 mL) and drying under vacuo at 70° C. for 16 hrs gave 741 mg of the title compound (78%) as a white solid in 99.9% purity by HPLC (MaxPlot detection between 230 and 400 nm).

Workup

  1. customthe reaction mixture was evaporated off
  2. customa white solid precipitated out
  3. filtrationFiltration
  4. washwashing with MeOH (2×3 mL)
  5. customdrying under vacuo at 70° C. for 16 hrs

Sources & evidence

ORD record
ord-2a47d0c256eb4ae0b67d8477381366be
Source dataset
uspto-grants-2010_04
Patent number
US07696231B2

Reaction notes

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