反应详情

To a suspension of methyl 4-(1H-tetrazol-5-yl)benzoate (1.00 g, 4.16 mmol) in EtOH (15 mL) was added hydrazine hydrate (3.0 mL). After stirring for 15 hrs at reflux, the reaction mixture was allowed to warm up to rt. A white solid precipitated out. Filtration, washing with EtOH (2×3 mL), EtOH/water (2×3 mL) and water (2×3 mL) and drying under vacuo at 70° C. for 5 hrs gave 677 mg of the title compound as a white solid in a 80% yield.

1. temperatureat reflux
2. customA white solid precipitated out
3. filtrationFiltration
4. washwashing with EtOH (2×3 mL), EtOH/water (2×3 mL) and water (2×3 mL)
5. customdrying under vacuo at 70° C. for 5 hrs