2-Fluoro-4-hydroxybenzoic Acid → (2-Fluoro-4-hydroxy-phenyl)-[2-(S)(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone

HRID 642181Notes

Reaction equation

HRID 642181 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.[CH3:12][C@@H:13]1[CH2:17][CH2:16][CH2:15][N:14]1[CH2:18][C@@H:19]1[CH2:23][CH2:22][CH2:21][NH:20]1>>[F:1][C:2]1[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:3]=1[C:4]([N:20]1[CH2:21][CH2:22][CH2:23][C@H:19]1[CH2:18][N:14]1[CH2:15][CH2:16][CH2:17][C@H:13]1[CH3:12])=[O:6]

Participants

3

Reactant 2

HCID 27833982-Fluoro-4-hydroxybenzoic AcidHCID 46911921(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine

Product 1

HCID 11960537(2-Fluoro-4-hydroxy-phenyl)-[2-(S)(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone

Procedure

The title compound is prepared in a manner substantially analogous to Procedure A from 2-fluoro-4-hydroxybenzoic acid and 2-(R)-Methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (ES+) 307.3

Sources & evidence

ORD record
ord-54472061dfa64c7fbbd80c315d20d2da
Source dataset
uspto-grants-2010_04
Patent number
US07696234B2

Reaction notes

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