(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine → [2,6-Difluoro-4(pyridin-2-ylmethoxy)-phenyl]-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone

HRID 642206Notes

Reaction equation

HRID 642206 reaction equation
CO[C:3](=[O:20])[C:4]1[C:9]([F:10])=[CH:8][C:7]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)=[CH:6][C:5]=1[F:19].[CH3:21][C@@H:22]1[CH2:26][CH2:25][CH2:24][N:23]1[CH2:27][C@@H:28]1[CH2:32][CH2:31][CH2:30][NH:29]1>>[F:10][C:9]1[CH:8]=[C:7]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH:6]=[C:5]([F:19])[C:4]=1[C:3]([N:29]1[CH2:30][CH2:31][CH2:32][C@H:28]1[CH2:27][N:23]1[CH2:24][CH2:25][CH2:26][C@H:22]1[CH3:21])=[O:20]

Participants

3

Reactant 2

HCID 46911921(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidineHCID 576851242,6-Difluoro-4-(pyridin-2-ylmethoxy)-benzoic Acid Methyl Ester

Product 1

HCID 11575240[2,6-Difluoro-4(pyridin-2-ylmethoxy)-phenyl]-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone

Procedure

The title compound is prepared in a manner substantially analogous to Procedure F from 2,6-Difluoro-4-(pyridin-2-ylmethoxy)-benzoic acid methyl ester and 2-(R)-Methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (ES+) 416.2

Sources & evidence

ORD record
ord-2bb1813f0592406e93861004505b74c6
Source dataset
uspto-grants-2010_04
Patent number
US07696234B2

Reaction notes

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