(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine → [2-Fluoro-4-(4-methanesulfonyl-benzyloxy)-phenyl]-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone

HRID 642211Notes

Reaction equation

HRID 642211 reaction equation
CO[C:3](=[O:23])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:14][CH:13]=2)=[CH:6][C:5]=1[F:22].[CH3:24][C@@H:25]1[CH2:29][CH2:28][CH2:27][N:26]1[CH2:30][C@@H:31]1[CH2:35][CH2:34][CH2:33][NH:32]1>>[F:22][C:5]1[CH:6]=[C:7]([O:10][CH2:11][C:12]2[CH:13]=[CH:14][C:15]([S:18]([CH3:21])(=[O:19])=[O:20])=[CH:16][CH:17]=2)[CH:8]=[CH:9][C:4]=1[C:3]([N:32]1[CH2:33][CH2:34][CH2:35][C@H:31]1[CH2:30][N:26]1[CH2:27][CH2:28][CH2:29][C@H:25]1[CH3:24])=[O:23]

Participants

3

Reactant 2

HCID 46911921(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidineHCID 576851252-Fluoro-4-(4-methanesulfonyl-benzyloxy)-benzoic Acid Methyl Ester

Product 1

HCID 11612583[2-Fluoro-4-(4-methanesulfonyl-benzyloxy)-phenyl]-[2-(S)-(2-(R)-methyl-pyrrolidin-1-ylmethyl)-pyrrolidin-1-yl]-methanone

Procedure

The title compound is prepared in a manner substantially analogous to Procedure F from 2-fluoro-4-(4-methanesulfonyl-benzyloxy)-benzoic acid methyl ester and 2-(R)-Methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (ES+) 475.2

Sources & evidence

ORD record
ord-77f28e25ed194d7c9386166b1d8a0c91
Source dataset
uspto-grants-2010_04
Patent number
US07696234B2

Reaction notes

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