Ethyl 2-((tert-butoxycarbonyl)amino)acetate → 1-Benzyl-4,5-dibromo-2-[(tert-butoxycarbonyl-ethoxycarbonylmethyl-amino)-methyl]-1H-pyrrole-3-carboxylic acid ethyl ester

HRID 642222Notes

Reaction equation

HRID 642222 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:10]([Br:11])=[C:9]([Br:12])[N:8]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:7]=1[CH2:20]Br)=[O:5])[CH3:2].[CH2:22]([O:24][C:25](=[O:35])[CH2:26][NH:27][C:28]([O:30][C:31]([CH3:34])([CH3:33])[CH3:32])=[O:29])[CH3:23]>>[CH2:1]([O:3][C:4]([C:6]1[C:10]([Br:11])=[C:9]([Br:12])[N:8]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:7]=1[CH2:20][N:27]([C:28]([O:30][C:31]([CH3:32])([CH3:34])[CH3:33])=[O:29])[CH2:26][C:25]([O:24][CH2:22][CH3:23])=[O:35])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 357729Ethyl 2-((tert-butoxycarbonyl)amino)acetateHCID 684263681-Benzyl-4,5-dibromo-2-bromomethyl-1H-pyrrole-3-carboxylic acid ethyl ester

Product 1

HCID 684260571-Benzyl-4,5-dibromo-2-[(tert-butoxycarbonyl-ethoxycarbonylmethyl-amino)-methyl]-1H-pyrrole-3-carboxylic acid ethyl ester

Procedure

Prepared in analogy to that of Example 1(c) from 1-benzyl-4,5-dibromo-2-bromomethyl-1H-pyrrole-3-carboxylic acid ethyl ester and tert-butoxycarbonylamino-acetic acid ethyl ester. The title compound, ESI MS (m/z): 623 (M+Na+).

Sources & evidence

ORD record
ord-1dbac41543814bc4bac7787f020cb66e
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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