Ethyl 2-((tert-butoxycarbonyl)amino)acetate → 4,5-Dibromo-2-[(tert-butoxycarbonyl-ethoxycarbonylmethyl-amino)-methyl]-1-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

HRID 642248Notes

Reaction equation

HRID 642248 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:10]([Br:11])=[C:9]([Br:12])[N:8]([CH3:13])[C:7]=1[CH2:14]Br)=[O:5])[CH3:2].[CH2:16]([O:18][C:19](=[O:29])[CH2:20][NH:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH3:17]>>[CH2:1]([O:3][C:4]([C:6]1[C:10]([Br:11])=[C:9]([Br:12])[N:8]([CH3:13])[C:7]=1[CH2:14][N:21]([C:22]([O:24][C:25]([CH3:26])([CH3:28])[CH3:27])=[O:23])[CH2:20][C:19]([O:18][CH2:16][CH3:17])=[O:29])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 357729Ethyl 2-((tert-butoxycarbonyl)amino)acetateHCID 684265464,5-Dibromo-2-bromomethyl-1-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

Product 1

HCID 684282064,5-Dibromo-2-[(tert-butoxycarbonyl-ethoxycarbonylmethyl-amino)-methyl]-1-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

Procedure

Prepared in analogy to that of Example 1(c) from 4,5-dibromo-2-bromomethyl-1-methyl-1H-pyrrole-3-carboxylic acid ethyl ester and tert-butoxycarbonylamino-acetic acid ethyl ester. The title compound, ESI MS (m/z): 549 (M+Na+).

Sources & evidence

ORD record
ord-d68ee103155f423bbfb1b9928b571d71
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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