2-(4-Fluoro-phenyl)-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester → 2,3-Dibromo-4-hydroxy-1-methyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

HRID 642249Notes

Reaction equation

HRID 642249 reaction equation
C(OC(C1C(O)=C2C=C(C3C=CC(F)=CC=3)N(C3C=CC=CC=3)C2=CN=1)=O)C.C([O:31][C:32]([C:34]1[C:38]([Br:39])=[C:37]([Br:40])[N:36]([CH3:41])[C:35]=1[CH2:42][N:43](C(OC(C)(C)C)=O)[CH2:44][C:45]([O:47][CH2:48][CH3:49])=[O:46])=O)C>>[CH2:48]([O:47][C:45]([C:44]1[C:32]([OH:31])=[C:34]2[C:38]([Br:39])=[C:37]([Br:40])[N:36]([CH3:41])[C:35]2=[CH:42][N:43]=1)=[O:46])[CH3:49]

Participants

3

Reactant 2

HCID 684278502-(4-Fluoro-phenyl)-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl esterHCID 684282064,5-Dibromo-2-[(tert-butoxycarbonyl-ethoxycarbonylmethyl-amino)-methyl]-1-methyl-1H-pyrrole-3-carboxylic acid ethyl ester

Product 1

HCID 684265352,3-Dibromo-4-hydroxy-1-methyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester

Procedure

Prepared in analogy to that of 2-(4-fluoro-phenyl)-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester from 4,5-Dibromo-2-[(tert-butoxycarbonyl-ethoxycarbonylmethyl-amino)-methyl]-1-methyl-1H-pyrrole-3-carboxylic acid ethyl ester. The title compound, ESI MS (m/z): 377 (M+H+).

Sources & evidence

ORD record
ord-b65387aa43e642c885414a9c66b1bfef
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

Loading…