2-Methyl-1-phenyl-1H-indole-3-carboxylic acid ethyl ester → 2-Bromomethyl-1-phenyl-1H-indole-3-carboxylic acid ethyl ester
Reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:10](Br)=[C:9]([C:12]2C=C[C:15](F)=[CH:14][CH:13]=2)[N:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:7]=1[CH2:25][Br:26])=[O:5])[CH3:2].C(OC(C1C2C(=CC=CC=2)N(C2C=CC=CC=2)C=1C)=O)C>>[CH2:1]([O:3][C:4]([C:6]1[C:10]2[C:9](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:8]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:7]=1[CH2:25][Br:26])=[O:5])[CH3:2]Participants
3
Procedure
Prepared in analogy to that of 4-bromo-2-bromomethyl-5-(4-fluoro-phenyl)-1-phenyl-1H-pyrrole-3-carboxylic acid ethyl ester from 2-Methyl-1-phenyl-1H-indole-3-carboxylic acid ethyl ester. The title compound, 1H NMR (200 MHz, CDCl3): δ (ppm)=8.21 (d, 1H), 7.6-6.9 (m, 8H), 4.89 (s, 2H), 4.47 (q, 2H, J=7.4 Hz), 1.50 (q, 3H, J=7.4 Hz).
Sources & evidence
- ORD record
- ord-3987ee306c274b7084159b5bcc365854
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07696223B2
Reaction notes
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