Glycine → HCID 68427327, compound

Participants

Reaction Steps

2-(4-tert-Butyl-phenyl)-7-hydroxy-thiazolo[4,5-c]pyridine-6-carboxylic acid ethyl ester (100 mg, 0.28 mmol) and glycine (442 mg, 5.89 mmol) were suspended in 11.2 mL of 0.5 N sodium methoxide in methanol. The reaction was heated at reflux temperature overnight, cooled, and concentrated. The residue was dissolved in water (30 mL), and the solution was acidified to pH 1˜2 with 2 N HCl, extracted with ethyl acetate. The combined organic layers were dried, filtered and concentrated to produce 63 mg of a yellow solid. MS: (+) m/z 386.0 (M+1).

Provenance & Evidence