Benzo(B)Thiophene-2-Boronic Acid → HCID 68428560, compound

HRID 642391Notes

Reaction equation

HRID 642391 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[S:10][C:9](Br)=[N:8][C:7]=1[CH2:12][N:13]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][C:22]=1[O:29][CH3:30])[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:5])[CH3:2].[S:31]1[C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][C:34]=2[CH:33]=[C:32]1B(O)O>>[CH2:1]([O:3][C:4]([C:6]1[S:10][C:9]([C:32]2[S:31][C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][C:34]=3[CH:33]=2)=[N:8][C:7]=1[CH2:12][N:13]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][C:22]=1[O:29][CH3:30])[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 2359Benzo(B)Thiophene-2-Boronic AcidHCID 684264542-Bromo-4-{[(2,4-dimethoxy-benzyl)-ethoxycarbonylmethyl-amino]-methyl}-thiazole-5-carboxylic acid ethyl ester

Product 1

HCID 68428560HCID 68428560, compound

Procedure

Prepared from 2-bromo-4-{[(2,4-dimethoxy-benzyl)-ethoxycarbonylmethyl-amino]-methyl}-thiazole-5-carboxylic acid ethy ester, example 81(b), and 1-benzothiophen-2-yl-boronic acid under conditions analogous to experimental example 81(c). MS: (+) m/z 555.4 (M+1).

Sources & evidence

ORD record
ord-7d2ad26bc9804244a4d2f61cb5528779
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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