Ethyl 2-methyl-3-pyrrolecarboxylate → HCID 68426167, compound

HRID 642412Notes

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[CH:9][NH:8][C:7]=1[CH3:11])=[O:5])[CH3:2].Br[CH2:13][CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1>>[CH2:1]([O:3][C:4]([C:6]1[CH:10]=[CH:9][N:8]([CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[C:7]=1[CH3:11])=[O:5])[CH3:2]

Participants

Reactant 2

HCID 136747Ethyl 2-methyl-3-pyrrolecarboxylate

HCID 137636Cyclohexane, (bromomethyl)-

Product 1

HCID 68426167HCID 68426167, compound

Procedure

Prepared from 2-methyl-1H-pyrrole-3-carboxylic acid ethyl ester, example 96(a), and (bromomethyl)cyclohexane under conditions analogous to experimental example 96(b). 1H NMR (200 MHz, CDCl3) δ 6.50 (1H, d, J=3.2 Hz), 6.43 (1H, d, J=3.2 Hz), 4.23 (2H, q, J=7.0 Hz), 3.62 (2H, d, J=6.6 Hz), 2.50 (3H, s), 1.78-0.88 (11H, m), and 1.33 (3H, t, J=7.0 Hz).

Sources & evidence

ORD record: ord-e736eb5a728e4120a78101737a6485f2
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07696223B2

Reaction notes

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