Ammonium formate → HCID 68427726, compound

HRID 642423Notes

Reaction equation

HRID 642423 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:31])=[C:8]2[C:16](Br)=[C:15]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)[N:14]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:9]2=[C:10]([C:12]#[N:13])[N:11]=1)=[O:5])[CH3:2].C([O-])=O.[NH4+]>[Pd]>[CH2:1]([O:3][C:4]([C:6]1[C:7]([OH:31])=[C:8]2[CH:16]=[C:15]([C:18]3[CH:23]=[CH:22][C:21]([F:24])=[CH:20][CH:19]=3)[N:14]([C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=3)[C:9]2=[C:10]([C:12]#[N:13])[N:11]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 2723923Ammonium formateHCID 68427759HCID 68427759, compound

Product 1

HCID 68427726HCID 68427726, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Prepared in analogy to that of Example 6(a) from 3-bromo-7-cyano-2-(4-fluoro-phenyl)-4-hydroxy-1-phenyl-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid ethyl ester, ammonium formate and Pd/C. The title compound, ESI MS (m/z): 402 (M+H)+.

Sources & evidence

ORD record
ord-a2bb92ddc8dc45adb090ef6c171ad23b
Source dataset
uspto-grants-2010_04
Patent number
US07696223B2

Reaction notes

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